N3-C2-NHS ester

CAS No. 850180-76-6

N3-C2-NHS ester( —— )

Catalog No. M33553 CAS No. 850180-76-6

N3-C2-NHS ester (3-Azidopropanoic acid NHS ester) is an ADC linker, which is a cross-linking agent for macromolecular compounds, and can be used for the synthesis of antibody-coupled reactive molecules (ADCs).

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    N3-C2-NHS ester
  • Note
    Research use only, not for human use.
  • Brief Description
    N3-C2-NHS ester (3-Azidopropanoic acid NHS ester) is an ADC linker, which is a cross-linking agent for macromolecular compounds, and can be used for the synthesis of antibody-coupled reactive molecules (ADCs).
  • Description
    N3-C2-NHS ester is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N3-C2-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Antibody Drug Conjugates (ADC)
  • Target
    ADCs Linker/Click Chemistry
  • Recptor
    ADC Linker
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    850180-76-6
  • Formula Weight
    212.16
  • Molecular Formula
    C7H8N4O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (471.34 mM; Ultrasonic )
  • SMILES
    [N-]=[N+]=NCCC(=O)ON1C(=O)CCC1=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Gregson SJ, et al. Pyrrolobenzodiazepine Dimer Antibody-Drug Conjugates: Synthesis and Evaluation of Noncleavable Drug-Linkers. J Med Chem. 2017 Dec 14;60(23):9490-9507.?
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